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Optibrium and University of Nottingham collaborate on innovative teaching programme

Optibrium logo 23.10.18University of Nottingham logo 3.12.18Drug discovery software developer Optibrium has entered into a collaboration with the University of Nottingham in which the company’s StarDrop software will be available to a number of fourth-year MSci Chemistry project students at the university as part of their training in modern drug discovery. The software will be used as an aid in the design of potential new candidate compounds for integrin inhibition in fibrotic diseases and malaria as part of a collaboration with GSK. Optibrium will also provide teaching on the application of software for drug discovery in support of an initiative to provide students with the most relevant courses for a career in the pharmaceutical industry.

Applying Optibrium’s StarDrop software and its unique drug discovery capabilities will enable the students to, for example, characterise properties for known drugs, understand the structure-activity relationships in existing project data and then design new candidate compounds using industry-leading predictive models.

Fibrotic diseases account for about 45% of deaths in the industrialised world, and there is an increasing need for improved treatment options. The key common element causing fibrosis is the build-up of scar tissue in the extracellular matrix of certain organs, in particular the kidneys, liver, lungs and skin. As part of the design for new candidate drug compounds, students at the University of Nottingham will study integrin inhibition, targeting the disease-causing scar tissue.

Malaria is an infectious disease that is transmitted through the Anopheles mosquito. The World Health Organization reported in 2016 that about 212 million cases of malaria had occurred worldwide, resulting in 429,000 mortalities in 2015. A global target has been set to reduce the incidence of the disease and associated mortality by 90% by 2030, however current drug treatments are threatened by the emergence of drug-resistant malarial strains, increasing the need for novel drugs to treat and block transmission.

For further information about Optibrium and StarDrop visit and for further information about the School of Chemistry at the University of Nottingham and the GSK Carbon Neutral Laboratory for Sustainable Chemistry visit 

Last modified onMonday, 03 December 2018 10:31

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